Note: Shake oral suspension well before using. The concentrations of the reconstituted suspensions are as follows: Fluconazole Content per BottleĬoncentration of Reconstituted Suspension The length of your treatment depends on your condition and on how well you respond to fluconazole. 22 Itraconazole, in a dosage of 200 mg 23 or 400 mg 24 administered. You may need to take only one dose of fluconazole, or you may need to take fluconazole for several weeks or longer. A monthly 150-mg dose of orally administered fluconazole has been shown to reduce the incidence of recurrences by 50 percent. It is usually taken once a day, with or without food. Each bottle will deliver 35 mL of suspension. Fluconazole comes as a tablet and a suspension (liquid) to take by mouth. To reconstitute, add 24 mL of distilled water or Purified Water (USP) to fluconazole bottle and shake vigorously to suspend powder. Prepare a suspension at time of dispensing as follows: tap bottle until all the powder flows freely. (Where K=0.55 for children older than 1 year and 0.45 for infants.)ĭirections for Mixing the Oral Suspension
The following formula may be used to estimate creatinine clearance in children: When serum creatinine is the only measure of renal function available, the following formula (based on sex, weight, and age of the patient) should be used to estimate the creatinine clearance in adults:Īlthough the pharmacokinetics of fluconazole has not been studied in children with renal insufficiency, dosage reduction in children with renal insufficiency should parallel that recommended for adults. Further adjustment may be needed depending upon clinical condition. These are suggested dose adjustments based on pharmacokinetics following administration of multiple doses. Patients on hemodialysis should receive 100% of the recommended dose after each hemodialysis on non-dialysis days, patients should receive a reduced dose according to their creatinine clearance. After the loading dose, the daily dose (according to indication) should be based on the following table: Creatinine Clearance (mL/min) In patients with impaired renal function who will receive multiple doses of DIFLUCAN, an initial loading dose of 50 mg to 400 mg should be given. There is no need to adjust single dose therapy for vaginal candidiasis because of impaired renal function. Dosage In Patients With Impaired Renal Functionįluconazole is cleared primarily by renal excretion as unchanged drug.
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